Biomedical Technology and Biological engineering

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Biomedical Technology and Biological engineering

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What is biomedical technology?

Biomedical technology, also known as bioengineering, is a fascinating field of study that merges engineering principles with biological sciences and medicine. It focuses on developing innovative technologies to improve human health and well-being.

What is biomedical technology?

What is biomedical technology?

Biomedical technology, also known as bioengineering, is a fascinating field of study that merges engineering principles with biological sciences and medicine. It focuses on developing innovative technologies to improve human health and well-being.

What are the main features of biomedical technology?

  • Interdisciplinary Approach: Biomedical technology draws on a wide range of disciplines like engineering, biology, chemistry, medicine, and materials science to create solutions for healthcare challenges.
  • Innovation Driven: The field is constantly evolving, with researchers developing new technologies and devices to diagnose, treat, and prevent diseases.
  • Improving Healthcare: Biomedical technology aims to improve the effectiveness, efficiency, and accessibility of healthcare for patients.

What are important sub-areas in biomedical technology?

  • Biomaterials: Develops new materials that are compatible with the human body for use in implants, prosthetics, and drug delivery systems.
  • Biomechanics: Applies engineering principles to understand the mechanics of the human body, used in designing prosthetics, implants, and rehabilitation techniques.
  • Medical Imaging: Develops technologies like X-ray, MRI, and CT scans to diagnose diseases and monitor treatment progress.
  • Bioinstrumentation: Creates new medical devices and instruments for diagnosis, treatment, and monitoring of patients.
  • Tissue Engineering: Aims to engineer human tissues and organs for transplants and to study diseases.

What are key concepts in biomedical technology?

  • Biocompatibility: The ability of a material to interact with the body without causing harm or rejection.
  • Biomedical devices: Instruments, equipment, and implants used for diagnosis, treatment, and monitoring of medical conditions.
  • Biomedical engineering ethics: Considers the ethical implications of new technologies, such as patient privacy and access to healthcare.
  • Clinical trials: The process of testing new medical devices and treatments to ensure their safety and effectiveness.
  • Personalized medicine: Tailoring medical treatments to individual patients based on their genetic makeup and other factors.

Who are influential figures in biomedical technology?

  • Willem Kolff: A Dutch physician who pioneered the development of the artificial kidney dialysis machine.
  • Aida Ginzberg: An Italian-born hematologist who played a key role in developing leukemia treatments.
  • Robert Langer: An American chemical engineer who has made significant contributions to drug delivery systems and tissue engineering.

Why is biomedical technology important?

Biomedical technology is crucial because:

  • It has the potential to revolutionize healthcare by providing new tools for diagnosis, treatment, and prevention of diseases.
  • It can improve the quality of life for patients by offering innovative solutions for managing chronic conditions and disabilities.
  • It can help reduce healthcare costs by developing more efficient and effective treatments.

How is biomedical technology applied in practice?

Biomedical technology is applied in a wide range of healthcare settings:

  • Biomedical engineers design and develop medical devices and instruments used in hospitals, clinics, and research labs.
  • Biomaterials scientists develop new materials for use in implants, prosthetics, and drug delivery systems.
  • Tissue engineers work on creating tissues and organs for transplantation and drug discovery.
  • Medical imaging specialists operate and maintain imaging equipment used for diagnostics.
  • Biomechanics experts design prosthetics, implants, and rehabilitation techniques to improve mobility and function for patients.
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Summaries

Boeksamenvatting bij Medical Biochemistry - Baynes, Dominiczak - 3e druk

Boeksamenvatting bij Medical Biochemistry - Baynes, Dominiczak - 3e druk

Medische biochemie: Wat is de functie van koolhydraten en vetten? - Chapter 3

 

Koolhydraten en vetten zijn hoofdenergiebronnen en worden in het lichaam opgeslagen als energiereserves (glycogeen en triglyceriden). Daarnaast hebben zij een belangrijke structurele en regulerende functie. Het zijn sterk gereduceerde verbindingen met nogal wat C-H-bindingen. Koolhydraten zijn hydrofiel. De kleine koolhydraten zijn oplosbaar in water, terwijl de grote polymeren vaak onoplosbaar zijn. Vetten zijn echter onoplosbaar in water (hydrofoob), maar oplosbaar in organische oplossingen.

Koolhydraten

Een koolhydraat bevat veel hydroxylgroepen (–OH) koolstofketen. Het achtervoegsel -ose duidt op een suiker. De volgende suikers zijn in ons lichaam van belang:

  • Glucose (bloedsuiker)

  • Fructose (vruchtensuiker)

  • Lactose (melksuiker)

  • Sucrose (tafelsuiker)

  • Mannose

  • Galactose.

Koolhydraten worden meestal gekoppeld via covalente bindingen, waardoor disachariden, trisachariden, oligosachariden en polysachariden ontstaan. Sachariden die uit een enkele suiker zijn opgebouwd, noemen we homoglycanen. Sachariden met een complexe samenstelling van meerdere soorten suikers noemen we heteroglycanen. Daarnaast kunnen de suikermonomeren op verschillende manieren met elkaar gekoppeld worden: door middel van een zuurstof-glycoside binding of stikstof-glycoside binding. De verschillende verbindingen zorgen voor verschillende eigenschappen.

Het kleinste koolhydraat heeft 3 C-atomen. Van moleculen met minder C-atomen kan ons lichaam geen koolhydraten maken. Vetzuren worden in ons lichaam afgebroken tot moleculen met 2 C-atomen, deze kunnen dus niet worden omgezet tot suikers. Vetzuren kunnen energie opleveren, maar kunnen koolhydraten niet vervangen op plaatsen waar energie uit koolhydraten nodig is.

Lipiden

Over het algemeen komen lipiden op drie plaatsen in ons lichaam voor: in plasma, in vetweefsel en in membranen. Vetzuren bestaan uit lange alkaanzuren met meestal 16 of 18 C-atomen. Zij kunnen verzadigd of

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Boeksamenvatting bij Mark's Essentials of Medical Biochemistry - Lieberman - 2e druk

Boeksamenvatting bij Mark's Essentials of Medical Biochemistry - Lieberman - 2e druk

Essentie van medische biochemie: Wat is de functie van brandstofmetabolisme? - Chapter 1

 

De belangrijkste brandstoffen die we uit ons eten halen zijn koolhydraten, eiwitten en vetten. Katabolisme is het proces waarbij deze brandstoffen geoxideerd worden tot CO2 en H2O in onze cellen, waardoor energie vrijkomt. De energie die hierbij vrijkomt zorgt voor warmte en voor ATP (adenosine trifosfaat). ATP is betrokken bij veel processen in ons lichaam, zoals bio synthetische reacties (anabolisme), spier samentrekkingen en actief transport tussen membranen. Het maken en afbreken van ATP wordt de ATP-ADP cyclus genoemd.

Koolhydraten, eiwitten en vetten

De belangrijkste koolhydraten in het voedsel zijn zetmeel, sucrose, lactose, fructose en glucose. Zetmeel is een polysacharide, sucrose en lactose zijn disachariden en fructose en glucose zijn monosachariden. De poly- en disachariden worden verteerd tot monosachariden, omdat alleen monosachariden opgenomen kunnen worden in het bloed. Oxidatie van koolhydraten tot CO2 en H2O levert per gram ongeveer 4 kcal energie op.

Eiwitten zijn opgebouwd uit aminozuren. Eiwitten worden afgebroken tot aminozuren en deze worden opgenomen in het bloed. Bij de oxidatie van eiwitten tot CO2, H2O en NH4+ in het lichaam komt ongeveer 4 kcal aan energie vrij per gram.
Vetten zijn lipiden die bestaan uit triglyceriden. Als vetten worden afgebroken komt er per gram vet 9 kcal aan energie vrij. Als alcohol wordt

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